The role and mechanism of NSun2 in gastric cancer

To explore the role and function of RNA methyltransferase NSun2 in gastric cancer, NSun2 overexpression and knockdown gastric cancer cell lines were constructed, and a combination of protein two-dimensional electrophoresis and mass spectrometry analysis was done to identify potential NSun2 targets． NSun2 was found to promote the proliferation of gastric cancer cells in vitro． A total of 34 proteins were identified after proteomics analysis, including glutathione S-transferase P (GSTP1-1) and kinase C inhibitor protein 1 (KCIP-1), potential downstream targets of NSun2 in gastric cancer． Important insights into the molecular mechanisms underlying gastric cancer tumorigenesis and progression were gained．